Publications

See the Google Scholar version here.

Pore structure controls stability and molecular flux in engineered protein cages
L. Adamson, N. Tasneem, M. P. Andreas, W. Close, T. N. Szyszka, E. Jenner, R. Young, L. C. Cheah, A. Norman, F. Sainsbury, T. W. Giessen*, Y. H. Lau*
bioRxiv 2021. doi:10.1101/2021.01.27.428512

An artificial self-assembling nanocompartment for organising metabolic pathways in yeast
L. C. Cheah, T. Stark, L. S. R. Adamson, R. S. Abidin, Y. H. Lau, F. Sainsbury, C. E. Vickers
bioRxiv 2021. doi:10.1101/2021.01.30.428974

Functionalized double strain-promoted stapled peptides for inhibiting the p53-MDM2 interaction
K. Sharma, A. V. Strizhak, E. Fowler, W. Xu, B. Chappell, H. F. Sore, W. R. J. D. Galloway, M. N. Grayson*, Y. H. Lau*, L. S. Itzhaki*, D. R. Spring*
ACS Omega 2020, 5, 1157-1169. doi:10.1021/acsomega.9b03459

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
K. Sharma, A. V. Strizhak, E. Fowler, X. Wang, W. Xu, C. H. Jensen, Y. Wu, H. F. Sore, Y. H. Lau*, M. Hyvönen*, L. S. Itzhaki*, D. R. Spring*
Org. Biomol. Chem. 2019, 17, 8014-8018. doi:10.1039/C9OB01745C

Toolbox of diverse linkers for navigating the cellular efficacy landscape of stapled peptides
Y. Wu, A. Kaur, E. Fowler, M. M. Wiedmann, R. Young, W. R. J. D. Galloway, L. Olsen, H. F. Sore, A. Chattopadhyay, T. T.-L. Kwan, W. Xu, S. J. Walsh, P. de Andrade, M. Janecek, S. Arumugam, L. S. Itzhaki, Y. H. Lau*, D. R. Spring*
ACS Chem. Biol. 2019, 14, 526-533. doi:10.1021/acschembio.9b00063

Prokaryotic nanocompartments form synthetic organelles in a eukaryote
Y. H. Lau, T. W. Giessen, W. J. Altenburg, P. A. Silver
Nat. Commun. 2018, 9, 1311. doi:10.1038/s41467-018-03768-x

Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
J. Iegre, N. S. Ahmed, J. S. Gaynord, Y. Wu, K. M. Herlihy, Y. S. Tan, M. E. Lopes-Pires, R. Jha, Y. H. Lau, H. F. Sore, C. Verma, D. H. O’Donvan, N. Pugh, D. R. Spring
Chem. Sci. 2018, 9, 4638-4643. doi:10.1039/C8SC00284C

Molecular switches for any pH: a systematic study of the versatile coordination behaviour of cyclam scorpionands
Y. H. Lau, J. K. Clegg, J. R. Price, R. B. Marquart, M. H. Todd, P. J. Rutledge
Chem. Eur. J. 2018, 24, 1573-1585. doi:10.1002/chem.201703488

Synthetic genome recoding: new genetic codes for new features
J. Kuo, F. Stirling, Y. H. Lau, Y. Shulgina, J. C. Way, P. A. Silver
Curr. Genet. 2018, 64, 327-333. doi:10.1007/s00294-017-0754-z

Double click stapled peptides for inhibiting protein-protein interactions
K. Sharma, D. L. Kunciw, W. Xu, M. M. Wiedmann, Y. Wu, H. F. Sore, W. R. J. D. Galloway, Y. H. Lau, L. S. Itzhaki, D. R. Spring
Cyclic Peptides: From Bioorganic Synthesis to Applications 2018, ISBN 978-1-78262-528-5, 164-187. doi:10.1039/9781788010153-00164

Targeting the genome-stability hub Ctf4 by stapled-peptide design
Y. Wu, F. Villa, J. Maman, Y. H. Lau, L. Dobnikar, A. C. Simon, K. Labib, D. R. Spring, L. Pellegrini
Angew. Chem. Int. Ed. 2017, 56, 12866-12872. doi:10.1002/anie.201705611

Large-scale recoding of a bacterial genome by iterative recombineering of synthetic DNA
Y. H. Lau, F. Stirling, J. Kuo, M. A. P. Karrenbelt, Y. A. Chan, A. Riesselman, C. A. Horton, E. Schäfer, D. Lips, M. T. Weinstock, D. G. Gibson, J. C. Way, P. A. Silver
Nucleic Acids Res. 2017, 45, 6971-6980. doi:10.1093/nar/gkx415

Macrocyclized extended peptides: inhibiting the substrate-recognition domain of tankyrase
W. Xu, Y. H. Lau, G. Fischer, Y. S. Tan, A. Chattopadhyay, M. de la Roche, M. Hyvönen, C. Verma, D. Spring, L. Itzhaki
J. Am. Chem. Soc. 2017, 139, 2245-2256. doi:10.1021/jacs.6b10234

Development of a multifunctional benzophenone linker for peptide stapling and photoaffinity labelling
Y. Wu, L. B. Olsen, Y. H. Lau, C. H. Jensen, M. Rossmann, Y. R. Baker, H. F. Sore, S. Collins, D. R. Spring
ChemBioChem 2016, 17, 689-692. doi:10.1002/cbic.201500648

Double strain-promoted macrocyclization for the rapid selection of cell-active stapled peptides
Y. H. Lau, Y. Wu, M. Rossmann, B. X. Tan, P. de Andrade, Y. S. Tan, C. Verma, G. J. McKenzie, A. R. Venkitaraman, M. Hyvönen, D. R. Spring
Angew. Chem. Int. Ed. 2015, 54, 15410-15413. doi:10.1002/anie.201508416

A two-component ‘double-click’ approach to peptide stapling
Y. H. Lau, Y. Wu, P. de Andrade, W. R. J. D. Galloway, D. R. Spring
Nat. Protoc. 2015, 10, 585-594. doi:10.1038/nprot.2015.033

Peptide stapling techniques based on different macrocyclisation chemistries
Y. H. Lau, P. de Andrade, Y. Wu, D. R. Spring
Chem. Soc. Rev. 2015, 44, 91-102. doi:10.1039/c4cs00246f

Linear aliphatic dialkynes as alternative linkers for double-click stapling of p53-derived peptides
Y. H. Lau, P. de Andrade, G. J. McKenzie, A. R. Venkitaraman, D. R. Spring
ChemBioChem 2014, 15, 2680-2683. doi:10.1002/cbic.201402374

Investigating peptide sequence variations for 'double-click' stapled p53 peptides
Y. H. Lau, P. de Andrade, N. Sköld, G. J. McKenzie, A. R. Venkitaraman, C. Verma, D. P. Lane, D. R. Spring
Org. Biomol. Chem. 2014, 12, 4074-4077. doi:10.1039/c4ob00742e

Functionalised staple linkages for modulating the cellular activity of stapled peptides
Y. H. Lau, P. de Andrade, S.-T. Quah, M. Rossmann, L. Laraia, N. Sköld, T. J. Sum, P. J. E. Rowling, T. L. Joseph, C. Verma, M. Hyvönen, L. S. Itzhaki, A. R. Venkitaraman, C. J. Brown, D. P. Lane, D. R. Spring
Chem. Sci. 2014, 5, 1804-1809. doi:10.1039/c4sc00045e

Efficient synthesis of Fmoc-protected azido amino acids
Y. H. Lau, D. R. Spring
Synlett 2011, 1917-1919. doi:10.1055/s-0030-1260950

A click fluorophore sensor can distinguish Cu(II) and Hg(II) via selective anion-induced demetallation
Y. H. Lau, J. Price, M. H. Todd, P. J. Rutledge
Chem. Eur. J. 2011, 17, 2850-2858. doi:10.1002/chem.201002477

Chemical sensors that incorporate click-derived triazoles
Y. H. Lau, P. J. Rutledge, M. Watkinson, M. H. Todd
Chem. Soc. Rev. 2011, 40, 2848-2866. doi:10.1039/c0cs00143k

Synthesis, electrochemistry and metal binding properties of monosubstituted ferrocenoyl peptides with thioether-containing sidechains
C. C. G. Scully, Y. H. Lau, P. Jensen, P. J. Rutledge
J. Organomet. Chem. 2011, 696, 715-721. doi:10.1016/j.jorganchem.2010.09.056