Research

We are architects of the molecular world. We use organic chemistry and synthetic biology to control the shape and assembly of the molecules of life - peptides and proteins - to design new medicines, materials, and catalysts.

We are based in the School of Chemistry at the University of Sydney. We collaborate widely with research groups locally and internationally.
Our group is associated with the Sydney Nano Institute, the Drug Discovery Initiative, the ARC Centre of Excellence in Peptide and Protein Science, and the ARC Centre of Excellence in Synthetic Biology.

The two primary areas of research currently in our lab are:

1. Drug discovery and synthetic chemistry - Telomeres
Cyclised peptides and fragments as therapeutic candidates for targeting telomere-associated proteins in cancer.

2. Synthetic biology and protein engineering - Compartmentalisation
Encapsulin protein cages as synthetic organelles for biomanufacturing.

Feel free to contact Yu Heng to learn more!

The Incubator

At the School of Chemistry, we have established a bio-nano space for doing cross-disciplinary chemical science. This space, which we like to call The Incubator, houses the capacity to conduct synthesis, molecular biology, bacterial culture, protein production and biophysical analysis.

The Incubator is a collaboration between the Lau group and the DNA group of Dr Shelley Wickham.

Our equipment facilites include two AKTA Pure FPLC protein purification systems, HPLC-SEC-MALS for protein characterisation, ChemiDoc system incl. fluorescence/NIR imaging, Olympus IX-81 inverted microscope, PCR machines, autoclave, centrifuges, incubators and shakers.

Check out our photos of the Incubator lab space =)